The relationship between sex and brain volume in a diverse sample of older adults differs by age group

The relationship between sex and brain region volume may vary by age group. Female sex was associated with smaller occipital and greater ventricular volumes at younger ages, but not at older ages. Further research is needed to elucidate drivers of these sex by age group differences and if they are associated with cognition.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_100440
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The relationship between sex and brain volume in a diverse sample of older adults differs by age group

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Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

The relationship between sex and brain volume in a diverse sample of older adults differs by age group

Sirena Gutierrez, Molly R. LaPoint, Batool Rizvi, María M. M. Corrada, Rachel A. Whitmer, Paola Gilsanz
article en

Abstract

The relationship between sex and brain region volume may vary by age group. Female sex was associated with smaller occipital and greater ventricular volumes at younger ages, but not at older ages. Further research is needed to elucidate drivers of these sex by age group differences and if they are associated with cognition.

Alzheimer s & DementiaVol. 21(S2)
Kaiser Permanente (US), University of California, San Francisco (US), University of California, Irvine (US), University of California, Davis (US)
Quality Education
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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