Examination of mitochondrial function and synaptic proteins in male and female Alzheimer's disease postmortem brain
We demonstrate differences in Akt signaling and mitochondrial content in PFC samples from AD donors. Additionally, this study shows greater changes in metabolic signaling in females than in males, and that this dysregulation in signaling with AD development is unique to females when compared to males.
Authors
- Alexander J.T. Yang (ORCID: https://orcid.org/0000-0002-7758-9795)
- Ahmad Mohammad
- Robert W. E. Crozier (ORCID: https://orcid.org/0000-0002-2146-5769)
- Evangelina Tsiani
- Gaynor E. Spencer (ORCID: https://orcid.org/0000-0001-8927-6844)
- Adam J. MacNeil (ORCID: https://orcid.org/0000-0002-4749-8120)
- Rebecca E. K. MacPherson (ORCID: https://orcid.org/0000-0002-1577-2658)
- Paula Duarte‐Guterman
- Lucas Maddalena
- Jeffery Stuart
Institutions
- University of Toronto (CA)
- Brock University (CA)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105880
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00