Utilization of a stem cell‐derived 3D Alzheimer's Disease neurosphere model to investigate the role of ApoE on neuronal/Glial interaction

This work provides validation of a protocol for the generation of hiPSC-derived neurospheres consisting of neurons, astrocytes and microglia. Demonstrating its value as a disease model system for the study of ApoE and AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105390
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Utilization of a stem cell‐derived 3D Alzheimer's Disease neurosphere model to investigate the role of ApoE on neuronal/Glial interaction

Haakon B. Nygaard, Ada J. Lin, J. Qing Huang, Stefan Wendt et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Utilization of a stem cell‐derived 3D Alzheimer's Disease neurosphere model to investigate the role of ApoE on neuronal/Glial interaction

Haakon B. Nygaard, Ada J. Lin, J. Qing Huang, Stefan Wendt, Christopher Lee
article en

Abstract

This work provides validation of a protocol for the generation of hiPSC-derived neurospheres consisting of neurons, astrocytes and microglia. Demonstrating its value as a disease model system for the study of ApoE and AD.

Alzheimer s & DementiaVol. 21(S1)
University of British Columbia (CA)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Utilization of a stem cell‐derived 3D Alzheimer's Disease neurosphere model to investigate the role of ApoE on neuronal/Glial interaction — Haakon B. Nygaard, Ada J. Lin, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS