Spatially distinct accretion of docosahexaenoic acid and eicosapentaenoic acid in a mouse model of Alzheimer's disease prior to plaque deposition
Novel lipid species and metabolic pathways are dysregulated during aging and in a mouse model of AD. Spatial lipidomic studies using DESI-IMS have the potential to identify novel and regionally specific lipid biomarkers in normal aging and AD.
Authors
- Jason Mares
- Nicholas Bartelo
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Artur Lazarian
- Krista Minéia Wartchow (ORCID: https://orcid.org/0000-0003-4572-3600)
- William Jones Dartora (ORCID: https://orcid.org/0000-0002-6164-0031)
- Tal Nuriel (ORCID: https://orcid.org/0000-0002-5252-8048)
- Ana Paula Costa
- Laura Beth Beth McIntire
- Jan Krumsiek
Institutions
- University of Pittsburgh (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- MIND Research Institute (US)
- Institute on Aging (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107792
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00