Sleep‐wake variation in body temperature regulates tau phosphorylation, secretion and splicing
Overall, these findings demonstrate that tau phosphorylation, secretion, and splicing follow a circadian pattern primarily regulated by BT and sleep. Given the prevalence of sleep disruptions and thermoregulatory deficits in AD, this study offers new insight into how tau pathology may develop and spread.
Authors
- Brendan P. Lucey (ORCID: https://orcid.org/0000-0001-5400-825X)
- Nicolas Sergeant
- Emmanuel Planel
- Esther M Blessing
- Geoffrey Canet
Institutions
- Inserm (FR)
- Washington University in St. Louis (US)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre hospitalier de l'Université Laval (CA)
- Université Laval (CA)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107132
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00