Plasma pTau217 as a marker of both the current and future state of amyloid pathology in adults with DS
Plasma pTau217 effectively predicts amyloid-PET positivity in individuals with DS and generates continuous estimates of time-to-amyloid-positivity in individuals with cortical amyloid burden > 30 CL. However, it is not as useful for estimating time-to-positivity at lower amyloid pathology levels (10 - 30 CL). This specific plasma pTau217 assay may lack sensitivity for detecting early amyloid positivity in people with DS.
Authors
- Ziqiao Jiao
- Lauren T. Ptomey (ORCID: https://orcid.org/0000-0002-1705-1643)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- J. Lee
- Christy Hom (ORCID: https://orcid.org/0000-0003-0266-0961)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Zinayida Schlachetzki
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Jordan P. Harp (ORCID: https://orcid.org/0000-0003-2089-0883)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Shahid Zaman
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- Bradley T Christian
- Laura Ibanez
- Adam Brickman
- Ann D Cohen
- Frederick A Schmitt
- Elizabeth Head
- Michael S. Rafii
- Natalie C. Edwards
- Mark Mapstone
- H. Diana Rosas
- Melissa Petersen
Institutions
- University of Southern California (US)
- University of North Texas (US)
- Autism Research Institute (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Kentucky (US)
- University of Kansas (US)
- University of North Texas Health Science Center (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
- University of Kansas Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099356
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00