High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis

The combination of iPSC-based cell models and functional genomics allowed for systematic perturbation of AD and MS risk SNPs, revealing previously uncharacterized risk genes linking neuroimmune pathways to disease pathophysiology. Ongoing studies are exploring the role of altered expression levels of MAF, ELMO1 and other screen hits in microglial phenotypes, including effects on neurons and astrocytes in co-culture and organoid systems.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105086
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis

Keya Viswanathan, Olivia Corradin, Xochitl Luna, Rudolf Jaenisch et al.
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis

Keya Viswanathan, Olivia Corradin, Xochitl Luna, Rudolf Jaenisch, Michael D. Gallagher, Yiran Cheng, Katheryn EA Hazel, Bingbing Yuan, Heather Keys, Richard A. Young, George W Bell, Zeynep Aydin, Moritz List, Wenjuan Du
article en

Abstract

The combination of iPSC-based cell models and functional genomics allowed for systematic perturbation of AD and MS risk SNPs, revealing previously uncharacterized risk genes linking neuroimmune pathways to disease pathophysiology. Ongoing studies are exploring the role of altered expression levels of MAF, ELMO1 and other screen hits in microglial phenotypes, including effects on neurons and astrocytes in co-culture and organoid systems.

Alzheimer s & DementiaVol. 21(S1)
Whitehead Institute for Biomedical Research (US), Massachusetts Institute of Technology (US)
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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High‐throughput CRISPR screen of GWAS risk loci in human microglia reveals novel risk genes for Alzheimer's disease and multiple sclerosis — Keya Viswanathan, Olivia Corradin, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS