Associations of cognitive intraindividual variability and regional brain volumes vary by sex in the Baltimore Longitudinal Study of Aging
In a cognitively healthy sample, Executive IIV was sensitive to temporal, limbic, and subcortical volumes across sexes. Global and Executive IIV related to brain volumes (i.e., limbic and occipital) among older males, whereas Language IIV related to brain volumes (i.e., temporal, parietal, and occipital) among older females. Further work will test these associations longitudinally as well as determine potential sex-specific mechanisms (e.g., vascular, Alzheimer's disease) for these patterns.
Authors
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Caitlin M. Terao (ORCID: https://orcid.org/0000-0002-5506-9625)
- Fareshte R. Erani (ORCID: https://orcid.org/0000-0001-6517-7980)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Susan M. Resnick
- Yang An
- Katherine J. Bangen
- Sarah J Banks
Institutions
- Johns Hopkins University (US)
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Institute on Aging (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104393
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00