Improved ventilation inhomogeneity and lower LCI variability under ETI: Retrospective analysis in a pediatric cohort
ETI reduces ventilation inhomogeneity in children with CF, the magnitude of LCI reduction is strongly dependent on baseline disease severity. Within-patient LCI variability is reduced, indicating greater disease stability. LCI is a sensitive marker, improvements upon ETI treatment are well predictable particularly in early disease stages, observational data support its routine use in clinical monitoring of pediatric patients.
Authors
- Philipp Latzin (ORCID: https://orcid.org/0000-0002-5239-1571)
- Carmen Casaulta (ORCID: https://orcid.org/0000-0003-4754-1608)
- Bettina Frauchiger (ORCID: https://orcid.org/0000-0002-9519-9328)
- Elisabeth Kieninger (ORCID: https://orcid.org/0000-0003-1741-5221)
- Insa Korten (ORCID: https://orcid.org/0000-0002-6184-5280)
- Tabitha Arn-Roth
- Tessa Bernasconi
Institutions
- University Hospital of Bern (CH)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.jcf.2025.12.016
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00