Exploring the impact of childbirth on the association between white matter hyperintensity load and cognitive changes in post‐menopausal women at risk of Alzheimer's Disease
In CU post-menopausal women with no history of cardiovascular diseases, WMH volume and number of childbirths were not independently associated with cognitive outcome at 3 years. However, higher number of childbirths moderated the association between WMH and cognitive changes: women with higher WMH volume in the parietal lobes showed lesser cognitive decline, independently of amyloid burden. Results indicate that the impact of childbirth on cerebrovascular disease may be traceable decades after childbirth. Further studies are needed to investigate potential mechanisms linking pregnancy history with WMH and cognitive performance.
Authors
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- Armand González Escalante
- Jordi Huguet (ORCID: https://orcid.org/0000-0001-8420-4833)
- Ana Fernández‐Arcos
- Kaj Blennow
- Clara Gallay
- Oriol Grau‐Rivera
- Juan Domingo Gispert
- Marc Suárez‐Calvet
- Henrik Zetterberg
Institutions
- Universitat Pompeu Fabra (ES)
- University of California San Diego (US)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- The London College (GB)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Global Brain Health Institute (US)
- Hospital del Mar Research Institute (ES)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100808
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00