Chronic HIV Infection Association with Cognition and ADRD Plasma Biomarkers in Uganda
Older PLWH well-treated on ART in Uganda have cognitive performance and plasma ADRD biomarker levels comparable to demographically-matched people without HIV, consistent with recent studies showing cognitive impairment is less common among PLWH with viral suppression. Ongoing studies will further assess trends in increased cognitive impairment and p-tau217 in PLWH, and evaluate differences in ADRD prevalence and cognitive trajectories in this cohort.
Authors
- Roslyn Valdespino
- Noeline Nakasujja (ORCID: https://orcid.org/0000-0002-8163-4376)
- Samson Okello (ORCID: https://orcid.org/0000-0001-7377-6094)
- Godfrey Masette
- Meredith Greene (ORCID: https://orcid.org/0000-0002-6548-6078)
- Chen‐Pin Wang
- Tiffany F. Kautz (ORCID: https://orcid.org/0000-0001-7680-4708)
- Jeremy A. Tanner (ORCID: https://orcid.org/0000-0001-9828-1776)
- Deanna R. Saylor (ORCID: https://orcid.org/0000-0002-9297-0244)
- Edna Tindimwebwa (ORCID: https://orcid.org/0000-0003-4255-2818)
- Zahra Reynolds (ORCID: https://orcid.org/0000-0003-0668-6798)
- Katherine L. Possin (ORCID: https://orcid.org/0000-0002-6623-3793)
- Amy Werry
- Alexander C. Tsai (ORCID: https://orcid.org/0000-0001-6397-7917)
- Eliza Passell
- Jayandra J. Himali
- Elena Tsoy
- Flavia Atwine
- Seeley Janet
- Mark J Siedner
- Lawren VandeVrede
- Robert Paul
- Susanne S Hoeppner
- Stephen Asiimwe
- Gabrielle Hromas
- Sudha Seshadri
- Christine S Ritchie
Institutions
- University of North Carolina at Chapel Hill (US)
- Mbarara University of Science and Technology (UG)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- University of Missouri–St. Louis (US)
- Massachusetts General Hospital (US)
- London School of Hygiene & Tropical Medicine (GB)
- Joint Clinical Research Centre (UG)
- The University of Texas at San Antonio (US)
- Indiana University – Purdue University Indianapolis (US)
- Makerere University (UG)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_098870
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00