Association of whole genome sequencing variants with time to Alzheimer's disease

Our preliminary findings highlight the critical role of APOE in the timing of AD onset, while also identifying potential novel loci associated with the disease. Except for APOE, there was limited overlap between our Cox GWAS results and those from case-control GWAS, suggesting distinct genetic factors influencing AD risk over time. Meta-analysis of the results from the two datasets, along with assessment of rarer variants, are underway. We will also perform multi-ancestral analysis and seek to expand the sample size for black and Hispanic populations.