Amantadine for multiple sclerosis-related fatigue: a systematic review and meta-analysis of randomized controlled trials
This meta-analysis suggests that amantadine is not effective for treating MS-related fatigue and is associated with an increased risk of adverse effects, particularly insomnia. These results cast doubt on its continued first-line use.
Authors
- Pedro Henrique Almeida Fraiman (ORCID: https://orcid.org/0000-0002-5250-8602)
- Yohanna Idsabella Rossi (ORCID: https://orcid.org/0000-0002-4067-2771)
- Filipe Sarmento (ORCID: https://orcid.org/0000-0001-6972-6414)
- Aishwarya Koppanatham (ORCID: https://orcid.org/0009-0000-5737-4474)
- Murilo Cruccioli
- Jorge Ferreira Jasmineiro Pitanga (ORCID: https://orcid.org/0009-0009-6222-4142)
- Pedro Henrique Teixeira Carneiro
- Letícia Torres da Silva
Institutions
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Universidad de Buenos Aires (AR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidade de Santo Amaro (BR)
- Rush University (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Neurodegenerative Disease Management
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1080/17582024.2025.2607678
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00