From marmosets to man: generating a protocol for directly converted neurons to advance Alzheimer's Disease research

Our novel protocol facilitates the study of cellular mechanisms with minimally invasive techniques, maximizing insights gained from marmoset models. This invaluable in vitro platform will also permit high-throughput drug screening, safer toxicology assessment, and in-depth mechanistic investigation of normal brain aging and AD pathogenesis, thus advancing translatable therapeutic opportunities for AD intervention.