Genome‐wide association study for Alzheimer's disease related complement components and regulators

Our study identified significant associations between plasma levels of complement proteins and domain-specific cognitive scores, highlighting their potential relevance to Alzheimer's disease (AD) pathology. These findings provide valuable insights into the genetic regulation of complement pathways in AD and suggest potential mechanisms underlying their role in cognitive decline.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_107268
Primary Topic
Complement system in diseases
Type
article
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article

Genome‐wide association study for Alzheimer's disease related complement components and regulators

Gyungah R Jun, Samantha Clayton
Alzheimer s & Dementia
Complement system in diseases
article

Genome‐wide association study for Alzheimer's disease related complement components and regulators

Gyungah R Jun, Samantha Clayton
article en

Abstract

Our study identified significant associations between plasma levels of complement proteins and domain-specific cognitive scores, highlighting their potential relevance to Alzheimer's disease (AD) pathology. These findings provide valuable insights into the genetic regulation of complement pathways in AD and suggest potential mechanisms underlying their role in cognitive decline.

Alzheimer s & DementiaVol. 21(S1)
Boston University (US)
Openalex Percentile: Top 36%
Complement system in diseases
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Genome‐wide association study for Alzheimer's disease related complement components and regulators — Gyungah R Jun, Samantha Clayton · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS