Correlates of white matter hyperintensities in Royal Canadian Air Force pilots and aircrew
Canadian military aircrew in the RCAF have a higher burden of WMH compared to normal controls. The findings suggest that increases in WMH volumes, potentially due to extreme occupational and physiological stressors from long exposure to high performance flights, are associated with subtle neurocognitive impairment. Future analyses will examine the potential modulating effects related to changes in blood-based neurological injury biomarkers.
Authors
- Melissa F. Holmes
- Shawn G. Rhind (ORCID: https://orcid.org/0000-0003-2300-0620)
- R.W. Miles
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Christopher J.M. Scott (ORCID: https://orcid.org/0000-0002-3236-7523)
- Miriam Palmer
- Gary Gray
- Kristen King
- Vincent N Marraffino
- Joan Saary
- Alex P Di Battista
- Sandra E. Black
- Oshin Vartanian
- Fuqiang Gao
- Shamus Allen
Institutions
- Defence Research and Development Canada (CA)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Scarborough Health Network (CA)
- Canadian Armed Forces (CA)
- Health Sciences Centre (CA)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_099047
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00