Evaluation of lithium carbonate treatment in a mouse model of Down syndrome using positron emission tomography
Trisomic animals had an increase of both PET tracers uptake at 14 months, indicating the presence of neuroinflammation. Chronic lithium treatment prevented these alterations suggesting an anti-neuroinflammatory effect that might be better comprehended in future studies.
Authors
- Carolina Aparecida de Faria Almeida (ORCID: https://orcid.org/0000-0002-1231-2496)
- Carlos Alberto Buchpiguel (ORCID: https://orcid.org/0000-0003-0956-2790)
- Larissa Estessi de Souza
- Jean Marques Brizola
- Lidia Emmanuela Wiazowski Spelta
- Chiara Maria Righini
- Daniele de Paula Faria
Institutions
- Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099817
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00