A Multi‐Ancestry TWAS in Alzheimer's Disease in African‐American, Hispanic/Latino and Non‐Hispanic White Populations
This study highlights the importance of multi-ancestry approaches in uncovering the genetic mechanisms influencing the molecular pathways involved in AD development. Zheng et al. found that the elevated TREML2 expression might exert pro-inflammatory and proliferation promoting effects on microglia in an AD context. Our findings underscore the potential of TREML2 as a target for further research and therapeutic intervention in AD. Increased sample sizes in studied populations will advance the identification of more AD-related genes.
Authors
- Penelope Benchek (ORCID: https://orcid.org/0000-0002-7385-087X)
- Jennifer E Below (ORCID: https://orcid.org/0000-0002-1346-1872)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Xinyu Sun
- Brian W Kunkle
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106624
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00