Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

CAA is particularly common in DSAD due to the genetic foundation of AD, which accelerates beta-amyloid pathology in both the brain parenchyma and blood vessels. This case underscores a significant gap in the literature concerning the coexistence of CAA in DSAD and acute ischemic stroke. Presently, there is no established evidence to guide management in such cases, and this issue is likely underreported due to limited data on reperfusion therapy for stroke in individuals with DS. The genetic characteristics of DSAD present a unique opportunity to explore the progression and interplay of these conditions, potentially providing valuable insights to inform treatment strategies and enhance outcomes for all patients.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_100856
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

Pol Camps‐Renom, Lucía Maure‐Blesa, Isabel Barroeta, María Carmona‐Iragui et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD)

Pol Camps‐Renom, Lucía Maure‐Blesa, Isabel Barroeta, María Carmona‐Iragui, José Enrique Arriola‐Infante, Alexandre Bejanin, Javier Arranz, Juan M. Fortea, M. Pichot, Mateus Rozalem Aranha, Íñigo Rodríguez‐Baz, Patricia Carbonell Fernández
article en

Abstract

CAA is particularly common in DSAD due to the genetic foundation of AD, which accelerates beta-amyloid pathology in both the brain parenchyma and blood vessels. This case underscores a significant gap in the literature concerning the coexistence of CAA in DSAD and acute ischemic stroke. Presently, there is no established evidence to guide management in such cases, and this issue is likely underreported due to limited data on reperfusion therapy for stroke in individuals with DS. The genetic characteristics of DSAD present a unique opportunity to explore the progression and interplay of these conditions, potentially providing valuable insights to inform treatment strategies and enhance outcomes for all patients.

Alzheimer s & DementiaVol. 21(S2)
Universitat Autònoma de Barcelona (ES), Instituto de Salud Carlos III (ES), Hospital de Sant Pau (ES), Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
Good health and well-being
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Challenges in Managing Cerebral Amyloid Angiopathy in Alzheimer's Disease: Insights from a Case of Down Syndrome‐associated Alzheimer Disease (DSAD) — Pol Camps‐Renom, Lucía Maure‐Blesa, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS