Imputing Alzheimer's disease phenotype in individuals with mild cognitive impairment for inclusion in gene discovery tests
Clinical, demographic, and biomarker data can be used to impute "caseness" for MCI individuals in genetic association tests. Even a small number of imputed MCI cases improved test statistics, suggesting greater benefits in larger datasets.
Authors
- Patrice Whitehead
- Michael Cuccaro
- Concepcion Silva
- Tianjie Gu
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Katrina Celis
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Jeffery M. M Vance
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- C. Golightly (ORCID: https://orcid.org/0000-0001-6256-9153)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Katalina McInerney
- Vanessa C. Rodriguez
- Goldie S Byrd
- Margaret Pericak‐Vance
- Jonathan L Haines
- Larry D Adams
- Farid Rajabli
- Jose J. Sanchez
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107001
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00