Contrasting physiological and pathological tau phosphorylation
Our findings highlight the possibility of differential regulation of tau phosphorylation in the developing and adult brains. Overall, by contrasting physiological and pathological phosphorylation patterns to tau, we discern tau proteoforms that are unique to the disease state, and thus strong candidates for therapeutic clearance.
Authors
- Marie Shimogawa (ORCID: https://orcid.org/0000-0002-8471-9375)
- Nima Naseri (ORCID: https://orcid.org/0000-0002-8868-1749)
- Elizabeth Rhoades (ORCID: https://orcid.org/0000-0002-1741-0650)
- Tom Tomlinson (ORCID: https://orcid.org/0000-0003-2884-6967)
- E. James Petersson
- Ophir Shalem
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107479
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00