The relationship between neuroinflammation and clinical features of dementia: An investigation of GFAP levels in Alzheimer's disease and related disorders

Neuroinflammation (GFAP levels) increases as individuals age, but to a greater extent in the presence of cognitive impairment (especially AD and VaD groups). Levels of peripheral inflammation (CRP) and BMI, were inversely associated with neuroinflammation. Elevated GFAP levels were not related to increased MRI white matter lesions or other elements of vascular disease. Further studies will investigate these complex relationships.