Identifying and Characterizing Comorbid Cerebral Amyloid Angiopathy in ADNI Participants using Boston Criteria Version 2.0

Systematic application of Boston Criteria version 2.0 using the ADNI database identified probable CAA in approximately 26% of participants with cognitive symptoms or deficits. Age, dementia severity, and APOE4 genotype may inform the likelihood of having CAA; however, probable CAA was identified in patients across the spectrum of cognitive impairment severity. These data underscore the value of rigorous assessment of CAA in patients with cognitive complaints broadly, and the need for research and clinical paradigms to meet the needs of such patients.