Alzheimer's mice model APP‐knock‐in displays altered hippocampal cholinergic function
Significant age-dependent alterations in cholinergic activity and neurotrophic factors were evident in hippocampus tissue of App<sup>NL-G-F</sup> mice, when compared to wild-type counterparts, underlining the importance of the cholinergic activity in relation to amyloid pathology.
Authors
- Simone Tambaro (ORCID: https://orcid.org/0000-0001-7000-7556)
- Homira Behbahani (ORCID: https://orcid.org/0000-0002-2612-0858)
- Bengt Linderoth
- Ruchi Gera (ORCID: https://orcid.org/0000-0002-7043-4096)
- Maria Eriksdotter
- Sumonto Mitra
- Per Nilsson
- Taher Darreh‐Shori
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106449
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00