Gamma‐secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease
These data and the associated literature strongly suggest that the course of ADAD is fundamentally shaped by variant-level effects on γ-secretase function and Aβ production. In addition to providing a unique line of support for the "amyloid hypothesis" of AD, these results provide compelling support for γ-secretase modulation (GSM) as a promising approach to treat AD.
Authors
- Stephanie A. Schultz (ORCID: https://orcid.org/0000-0001-8460-4415)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hyun‐Sik Yang
- Lei Liu
- Dennis J. Selkoe
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098877
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00