Circadian‐regulating nuclei in the human anterior hypothalamus demonstrate selective vulnerability to pathological effects of Alzheimer's disease
Our findings reveal that among these three AVP+ nuclei, the SCN is particularly vulnerable to early AD-related neurodegeneration, whereas the PVN accumulates tau and amyloid pathology without significant neuronal loss. The SON appears relatively resistant to AD pathology. These differential patterns suggest that intrinsic properties of neuronal populations and local microenvironments may contribute to selective vulnerability, providing a unique model to explore resilience mechanisms in AD.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Gowoon Son (ORCID: https://orcid.org/0000-0003-1173-2218)
- Song Hua Li
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Tia LaMore
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Li Zhu (ORCID: https://orcid.org/0000-0002-7804-907X)
- Thomas C. Neylan (ORCID: https://orcid.org/0000-0002-1572-2626)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Mihovil Mladinov (ORCID: https://orcid.org/0000-0002-4886-7119)
- Grace Judge
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
- Y. Chen
- Felipe Luiz Pereira
- Carlos Augusto Pasqualucci
- Yishu Chao
- William W. Seeley
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- Microsoft (Brazil) (BR)
- University Memory and Aging Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107235
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00