Increased Extra‐Synaptic Localisation of the Presynaptic Protein, SV2A, in the Human Alzheimer's Disease Brain
We show that SV2a is not expressed at all synapses, with a substantial proportion found elsewhere in neurons and glia. Therefore, SV2a as a biomarker may not reveal the true extent of synapse loss in AD.
Authors
- Sulin Liu (ORCID: https://orcid.org/0000-0002-6776-2216)
- Carola I. Radulescu (ORCID: https://orcid.org/0000-0003-4089-9295)
- Paul M. Matthews (ORCID: https://orcid.org/0000-0002-1619-8328)
- Samuel J K Barnes (ORCID: https://orcid.org/0000-0002-0679-4943)
- Johanna S Jackson
- Samrah Siddiqi
- Stanley Williams
- Rutvi Patel
- Leire Melgosa‐Ecenarro
Institutions
- UK Dementia Research Institute (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099018
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00