Longitudinal associations between blood‐based biomarkers of Alzheimer's disease and MRI‐measured cortical thickness and grey matter volume in subjective cognitive decline
These findings suggest that gray matter atrophy in individuals with SCD is associated with AD-related pathology as measured by blood-based biomarkers, especially GFAP. This highlights the potential of blood-based biomarkers as monitoring tools for structural brain changes and disease progression.
Authors
- Calvin Trieu (ORCID: https://orcid.org/0000-0001-6266-2198)
- Mardou S. S. A. van Leeuwenstijn
- Frederik Barkhof
- Lisa‐Marie Schlüter
- Ellen Dicks
- Wiesje M. van der Flier
- Lynn Boonkamp
- Charlotte E. Teunissen
- Argonde C. van Harten
Institutions
- Queen Mary University of London (GB)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100846
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00