Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology
Polygenic risk for AD influences WM integrity both directly and via AD pathology-dependent effects. Genetic susceptibility to preclinical AD pathology activates distinct biological processes that differentially affect WM integrity.
Authors
- Emma S. Luckett (ORCID: https://orcid.org/0000-0003-1777-4742)
- Luca Roccatagliata (ORCID: https://orcid.org/0000-0001-8029-3947)
- Luigi Lorenzini (ORCID: https://orcid.org/0000-0002-9756-881X)
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- André Altmann (ORCID: https://orcid.org/0000-0002-9265-2393)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- G. Pontillo
- Leonard Pieperhoff (ORCID: https://orcid.org/0009-0003-9003-4588)
- Pierre Payoux
- Frederik Barkhof
- Tiago Gil Oliveira
- Pablo Martínez‐Lage
- Craig Ritchie
- Arturo Brunetti
- Juan Domingo Gispert
- Alle Meije Wink
- Niccoló Tesi
- Henk Mutsaerts
- Lyduine E. Collij
Institutions
- Radboud University Nijmegen (NL)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Lund University (SE)
- Radboud University Medical Center (NL)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Federico II University Hospital (IT)
- Barcelonaβeta Brain Research Center (ES)
- The London College (GB)
- Ospedale Policlinico San Martino (IT)
- Amsterdam University Medical Centers (NL)
- Fundacion CITA Alzheimer (ES)
- University College London (GB)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098970
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00