First‐In‐Human, Single Ascending Dose and Food‐Effect Study in Healthy Volunteers of SUL‐238, a Novel Orally Administered Mitochondria‐Directed Drug Candidate

In this Phase 1, first-in-human, healthy volunteer study, 50-2000 mg single oral doses of SUL-238 were safe and well-tolerated, while demonstrating a favourable PK profile, and a high CSF penetration.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_100985
Primary Topic
Mitochondrial Function and Pathology
Type
article
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article

First‐In‐Human, Single Ascending Dose and Food‐Effect Study in Healthy Volunteers of SUL‐238, a Novel Orally Administered Mitochondria‐Directed Drug Candidate

Nadir Ulu, Murat Emre, Adrianus C. van der Graaf, Sedat Altuǧ et al.
Alzheimer s & Dementia
Mitochondrial Function and Pathology
article

First‐In‐Human, Single Ascending Dose and Food‐Effect Study in Healthy Volunteers of SUL‐238, a Novel Orally Administered Mitochondria‐Directed Drug Candidate

Nadir Ulu, Murat Emre, Adrianus C. van der Graaf, Sedat Altuǧ, Serhat Kozlu, Ahmet İnal, Daniël Henri Swart, Mustafa Mümtaz Mazıcıoğlu, Robert Henk Henning, Zafer Sezer, Guido Krenning
article en

Abstract

In this Phase 1, first-in-human, healthy volunteer study, 50-2000 mg single oral doses of SUL-238 were safe and well-tolerated, while demonstrating a favourable PK profile, and a high CSF penetration.

Alzheimer s & DementiaVol. 21(S5)
University Medical Center Groningen (NL), Istanbul Bilim University (TR), Ankara Sosyal Bilimler Üniversitesi (TR), Kayseri Eğitim ve Araştırma Hastanesi (TR), Istanbul University (TR), Erciyes University (TR)
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Openalex Percentile: Top 36%
Mitochondrial Function and Pathology
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First‐In‐Human, Single Ascending Dose and Food‐Effect Study in Healthy Volunteers of SUL‐238, a Novel Orally Administered Mitochondria‐Directed Drug Candidate — Nadir Ulu, Murat Emre, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS