Genetic covariance analysis of Alzheimer's disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry
These findings nominate PHLPP1 as a shared locus for both AD and stroke in individuals of African ancestry. Notably, a genome-wide significant signal in this locus was identified in an admixture mapping study of African Americans (Rajabli et al., 2023). Identification of shared molecular mechanisms between AD and CVD in different populations is useful for understanding the relationship between these two processes in all people.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Scott M. Williams (ORCID: https://orcid.org/0000-0002-4835-9544)
- Patrice Whitehead
- Michael Cuccaro
- Nicholas R. Ray
- Rufus Akinyemi (ORCID: https://orcid.org/0000-0001-5286-428X)
- Wanying Xu
- Samuel Diala
- Susan H. Blanton (ORCID: https://orcid.org/0000-0002-5433-3439)
- Mayowa Ogunronbi (ORCID: https://orcid.org/0000-0003-4104-2728)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Kazeem Akinwande (ORCID: https://orcid.org/0000-0002-1472-3344)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Jacob L. McCauley (ORCID: https://orcid.org/0000-0002-1805-1733)
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- Kyle Scott
- Reginald Obiako (ORCID: https://orcid.org/0000-0003-1769-8110)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Albert Akpalu (ORCID: https://orcid.org/0000-0002-4802-9852)
- Çağhan Kızıl (ORCID: https://orcid.org/0000-0002-8164-9762)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Njideka Okubadejo (ORCID: https://orcid.org/0000-0003-2975-8803)
- Ajneesh Kumar (ORCID: https://orcid.org/0000-0001-5513-4135)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- D. M. Ndetei
- Raj N Kalaria
- Katalina McInerney
- Izri M Martinez
- Luciana Bertholim Nasciben
- Andrew F Zaman
- Goldie S Byrd
- Elanur Yilmaz
- Sofia Moura
- Larry D Adams
- Farid Rajabli
- Allison M Caban‐Holt
- AfDC
- Brian W Kunkle
- Jonathan L Haines
- Olusegun Baiyewu
- Fulai Jin
- Adesola Ogunniyi
- Albertino Damasceno
- Margaret Pericak‐Vance
- Motunrayo Coker
- Kolawole Wahab
Institutions
- Ahmadu Bello University (NG)
- University of Ilorin (NG)
- University of Ghana (GH)
- University of Miami (US)
- Eduardo Mondlane University (MZ)
- University of Ibadan (NG)
- University of Lagos (NG)
- Columbia University Irving Medical Center (US)
- Newcastle Hospitals - Campus for Ageing and Vitality (GB)
- University School (US)
- Wake Forest University (US)
- Case Western Reserve University (US)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107411
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00