Multi‐omics integration highlights transposable elements as latent regulatory factors involved in the preclinical processes of Alzheimer's disease and related dementias‐ADRD
By integrating genomic and methylation data, we offer novel insights into the role of TEs in AD pathogenesis and their contribution to increased disease risk. Our ongoing work, leveraging ChIP-seq data on DNA accessibility (chromatin state), aims to further characterize these latent regulatory elements and their impact on gene regulation in a context-specific manner.
Authors
- Yinan Zheng (ORCID: https://orcid.org/0000-0002-2837-1634)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Chakkarai Sathyaseelan
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Jayandra J. Himali
- Qiong Yang
- Muralidharan Sargurupremraj
Institutions
- Boston University (US)
- Northwestern University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106069
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 0.00