Dexmedetomidine enhances recovery after gastrointestinal cancer surgery by protecting the endothelial glycocalyx: A randomized, double-blind, placebo-controlled study
Perioperative administration of DEX confers significant endothelial-protective effects by mitigating glycocalyx degradation, suppressing systemic inflammation, and promoting enhanced postoperative recovery. These findings support its clinical utility as a valuable adjunctive therapy in the perioperative management of patients undergoing oncologic gastrointestinal surgery.
Authors
- Yue Zhao (ORCID: https://orcid.org/0009-0009-6533-6465)
- Xianwen Hu (ORCID: https://orcid.org/0000-0001-7346-8585)
- Rong Zeng
- Yun Fang
- Chao-Liang Tang
- Rui-Xiang Wang
Institutions
- University of Science and Technology of China (CN)
- Anhui University (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Surgery
- Published
- 2025-12-25
- DOI
- https://doi.org/10.4240/wjgs.v17.i12.114628
- Citations
- 2
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 3.09