White matter integrity measures relate to distinct CSF proteomic profiles in non‐demented subjects dependent on amyloid status
These results provide new insights into the biological mechanisms underlying white matter integrity and its spatial relationship to AD pathology. The observed amyloid-dependent associations underscore the interplay between amyloid pathology and white matter damage, suggesting that interventions targeting synaptic organization, axonogenesis, and plasticity may hold promise for mitigating disease progression.
Authors
- Luca Roccatagliata (ORCID: https://orcid.org/0000-0001-8029-3947)
- Luigi Lorenzini (ORCID: https://orcid.org/0000-0002-9756-881X)
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- Diederick Martijn de Leeuw
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Mara ten Kate (ORCID: https://orcid.org/0000-0002-8290-8543)
- Frederik Barkhof
- Pieter Jelle Visser
- Charlotte E. Teunissen
- Betty M. Tijms
- Anouk den Braber
Institutions
- Amsterdam Neuroscience (NL)
- Ospedale Policlinico San Martino (IT)
- Amsterdam University Medical Centers (NL)
- University of Genoa (IT)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098829
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00