Regulatory Networks of circRNAs, miRNAs, and mRNAs in a APP/PS1 Mouse Model

Our results indicate a growing dysregulation of circRNAs in the APPswe/PSEN1dE9, suggesting they follow disease severity. The dysregulation of circRNAs previously described in humans highlights their evolutionary conservation and the advantage of studying them in animal models. Investigating the interactions among circRNAs, miRNAs, and mRNAs revealed genes associated with AD pathophysiology, such as neural differentiation, GABAergic signaling, stress response, and neuroinflammation, suggesting an impact on gene expression in regions vulnerable to the disease.