Beyond Gamma: Synergistic Potential of 10 Hz Alpha and 40 Hz Gamma Photobiomodulation in Alzheimer's Disease Treatment
Relying solely on 40 Hz gamma stimulation may limit therapeutic efficacy by neglecting the complementary benefits of 10 Hz. This study highlights the synergistic effects of 10 Hz alpha and 40 Hz gamma PBM, with higher frequencies potentially offering additional advantages. PBM's ability to modulate microtubular dynamics provides a foundation for exploring advanced frequency combinations. Integrating artificial intelligence could further optimize personalized, frequency-specific PBM protocols, paving the way for more effective AD interventions.
Authors
- Elisabetta Di Gregorio
- Davide Lazzari (ORCID: https://orcid.org/0000-0002-1186-9452)
- Janine Liburd
- Michael Staelens (ORCID: https://orcid.org/0000-0002-6401-0043)
- Mahroo Karimpoor (ORCID: https://orcid.org/0000-0002-6030-7309)
- Jack A. Tuszyński (ORCID: https://orcid.org/0000-0001-9976-0429)
- Nazanin Hosseinkhah (ORCID: https://orcid.org/0000-0003-0651-8145)
- Barbara Truglia (ORCID: https://orcid.org/0009-0008-3963-8315)
- Lew Lim
- Karthik Shankar
Institutions
- University of Alberta (CA)
- Politecnico di Torino (IT)
- University of Milan (IT)
- Okanagan College (CA)
- Turin Polytechnic University (UZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105314
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00