Psilocybin Maintains Better Brain Function in an Alzheimer’s Disease Model with Reduced Neuroinflammation and Improved Hippocampal Neurogenesis

Psilocybin treatment can maintain better brain function in an AD model without affecting amyloid-beta plaques. Improved brain function is likely due to psilocybin-induced reductions in neuroinflammatory signaling, enhanced hippocampal neurogenesis, and preservation of synapses.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_100589
Primary Topic
Psychedelics and Drug Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Psilocybin Maintains Better Brain Function in an Alzheimer’s Disease Model with Reduced Neuroinflammation and Improved Hippocampal Neurogenesis

Jay S. Patel, Prashanta Kumar Panda, V. Seetharama Rao, Sahithi Attaluri et al.
Alzheimer s & Dementia
Psychedelics and Drug Studies
article

Psilocybin Maintains Better Brain Function in an Alzheimer’s Disease Model with Reduced Neuroinflammation and Improved Hippocampal Neurogenesis

Jay S. Patel, Prashanta Kumar Panda, V. Seetharama Rao, Sahithi Attaluri, Maheedhar Kodali, Xiaolan Rao, ST Weintraub, Shama Rao, Yogish Somayaji, Leelavathi N. Madhu, Sanya Kotian, Ashok K Shetty, Bing Shuai, Goutham Shankar
article en

Abstract

Psilocybin treatment can maintain better brain function in an AD model without affecting amyloid-beta plaques. Improved brain function is likely due to psilocybin-induced reductions in neuroinflammatory signaling, enhanced hippocampal neurogenesis, and preservation of synapses.

Alzheimer s & DementiaVol. 21(S5)
The University of Texas at San Antonio Health Science Center (US), California Institute for Regenerative Medicine (US), Urology San Antonio (US), Texas A&M Health Science Center (US), Texas A&M University (US)
Good health and well-being
Openalex Percentile: Top 27%
Psychedelics and Drug Studies
DOIOpen Access PDFOpenAlex
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Psilocybin Maintains Better Brain Function in an Alzheimer’s Disease Model with Reduced Neuroinflammation and Improved Hippocampal Neurogenesis — Jay S. Patel, Prashanta Kumar Panda, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS