Coupling between global gray matter BOLD activity and CSF movement is associated with Aβ and tau burden in preclinical Alzheimer's disease
Contrary to our expectations, individuals with higher Aβ/tau showed stronger gBOLD-CSF anti-correlation. Reasons remain unclear, but it is possible that individuals with ATN were more likely to sleep during rsfMRI, leading to increased fluid movement. Our findings suggest the importance of adjusting for sleep-wake states when imaging brain fluid transport.
Authors
- Daniel B. Kay (ORCID: https://orcid.org/0000-0002-3362-7278)
- Hélène Benveniste (ORCID: https://orcid.org/0000-0003-1627-0219)
- Gawon Cho (ORCID: https://orcid.org/0000-0002-3512-8982)
- Brienne Miner (ORCID: https://orcid.org/0000-0002-3767-8849)
- Adam P. Mecca (ORCID: https://orcid.org/0000-0003-1982-5443)
- Xiao Liu
- Ryan S O'Dell
- Christopher H van Dyck
Institutions
- Brigham Young University (US)
- Pennsylvania State University (US)
- Yale University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106025
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00