Distinct patterns of age‐related volume alterations in subcortical grey matter
The analyses reveal that shrinkage of grey matter volume in subcortical areas is not the only reason behind age-related changes in structural brain characteristics; increases in the volumes of the left and right Caudate and Pallidum and the left Putamen in the older group demonstrate age-related brain inflammation due to immune system alterations, probably preceding pathogenesis of neurodegenerative diseases in some individuals.
Authors
- Fatemeh Tabassi Mofrad (ORCID: https://orcid.org/0000-0002-7324-6680)
- John Gallacher
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101472
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00