Quantitative EEG obtained from Dual‐Task paradigms for the study of preclinical populations at risk of Alzheimer Disease

The proposed experiment effectively extracted brain information that differentiates between carriers and non-carriers of the PSEN1-E280A variant. DTC values in the alpha band (frontal and central regions) and the beta band (central regions) exhibited larger effect sizes, suggesting that these areas are sensitive to preclinical cognitive and motor differences. The experimental paradigm and data-processing pipeline ensured the acquisition of EEG data with meaningful neurological information. This combination of novel biomarkers enhances non-invasive and portable tools for identifying ADAD carriers during preclinical stages.