Segmentation and registration of within‐subject 7 tesla ex vivo and 3 tesla in situ MRI to increase sensitivity of imaging biomarkers
Our proposed pipeline (purple-mri) accurately segments high-resolution exvivo MRI and performs registration to give one-to-one correspondence between multi-modal postmortem MRI. The developed pipeline sets the stage for exvivo to invivo registrations, which would enable stronger association studies between morphometry and histopathological examination.
Authors
- Pulkit Khandelwal (ORCID: https://orcid.org/0000-0003-1397-3496)
- Sydney Lim (ORCID: https://orcid.org/0000-0002-5359-4661)
- Laura Jonkman
- PA Yushkevich
- Louise van der Weerd
- Wilma D.J. Van de Berg
- Normal Aging Brain Collection Amsterdam
Institutions
- Leiden University (NL)
- Netherlands Institute for Neuroscience (NL)
- University of Applied Sciences Leiden (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101680
- Primary Topic
- Medical Image Segmentation Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00