Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes
Specific PT and NPT combinations, including donepezil+CT, rivastigmine+CR, and huperzine, showed notable cognitive benefits, while only PE significantly enhanced functional status. These findings suggest the potential for combined PT and NPT approaches in AD care; however, further research is needed to substantiate these results given the limited data on combination therapies.
Authors
- Masatha Thongpan
- Worapong Tearneukit
- Chitima Boongird (ORCID: https://orcid.org/0000-0002-7594-2460)
- Unyaporn Suthutvoravut
- Sasivimol Rattanasiri (ORCID: https://orcid.org/0000-0001-7213-6116)
- Wannisa Wongpipathpong (ORCID: https://orcid.org/0000-0001-5631-5472)
- Natthakorn Pongsettakul
- Gareth J. McKay
- Thunyarat Anothaisintawee
- Ammarin Thakkinstian
Institutions
- Queen's University Belfast (GB)
- Ramathibodi Hospital (TH)
- Somdet Chaopraya Institute of Psychiatry (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70858_097093
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00