Targeted chondrogenic differentiation of human MSCs using niosomes for SOX9 gene delivery: comparison of minicircle and conventional plasmids
Delivery of SOX9 plasmids via niosomes promotes enhanced chondrogenic differentiation of primary hMSCs in a 3D aggregate culture system, leading to the formation of hyaline-like cartilage tissue. This non-viral strategy represents a promising gene delivery platform for cartilage reparative therapies.
Authors
- Ana Rey‐Rico (ORCID: https://orcid.org/0000-0003-1682-498X)
- Junquera López-Seijas (ORCID: https://orcid.org/0000-0002-7295-0561)
- Sara Paniagua-Barro (ORCID: https://orcid.org/0009-0008-0925-5946)
- Alba Iglesias-Fente (ORCID: https://orcid.org/0000-0002-2052-7569)
- Alba Ramil-Bouzas
- Juan A. Fafián-Labora
Institutions
- Universidade da Coruña (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1186/s13287-025-04867-5
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00