The A431E PSEN1 mutation arising as a founder effect in Jalisco State in Mexico: clinical features, imaging, and neuropathological findings
As the number of persons at-risk for inheriting it has been estimated at 1,260, the A431E mutation in PSEN1 is an attractive target for both mutation-specific genetic interventions and for anti-AD therapy in general. Supported by P30AG066530, U01AG051218, R01AG062007, R01AG069013.
Authors
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_098880
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00