Does standalone/combined subchondral bone marrow-derived mesenchymal stem/stromal cell injection offer significantly better clinical benefit to intraarticular injection in knee osteoarthritis?
Targeting subchondral bone with BMAC addresses underlying OA pathology and may offer disease-modifying potential beyond symptom relief. These findings support a paradigm shift toward whole-joint biologic therapy, positioning the subchondral matrix as a therapeutic epicenter in OA management.
Authors
- Asawari Bapat
- Sathish Muthu
- Avinash Gandi Devadas
- Arulkumar Nallakumarasamy
- Swaminathan Ramasubramanian
- Sandeep Shrivastava
- Madhan Jeyaraman
- Naveen Jeyaraman
- Ravi Velamoor Rangarajan
Institutions
- Meenakshi Academy of Higher Education and Research (IN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Meenakshi Medical College Hospital and Research Institute (IN)
- Regenerative Medicine Institute (MX)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-12-25
- DOI
- https://doi.org/10.4252/wjsc.v17.i12.112778
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00