Genetics of circulating inflammatory proteins identifies a potential pathway linking Alzheimer's disease and depression

The MR analysis revealed IL-8 increases the risk of AD. The soluble CD40 receptor protects against the progression of depression. Previous studies have shown IL-8 induces abnormal expression of CD40 by microglia, which may contribute to the comorbidity of depression and AD. Our results also indicate that depression upregulates CD137 expression, a biomarker recognized for AD progression. Future research can explore the potential of CD137 as a biomarker for the co-diagnosis of depression and AD.