Impact of APOE3/E3 Astrocytes on APOE4/E4 Neuronal Phenotype

Nneurons with the same APOE genotype are more similar despite the genotypes of the treated ACM. The difference in response of neurons to ACM treatment suggests a potential donor effect, warranting further investigation. Yet, the morphology of neurons is affected by the co-cultured astrocytes, suggesting that the influence of co-cultured astrocytes is more salient that the neurons' genotype.