APOE‐relevant tau oligomer polymorphs differentially impair synaptic functioning
The APOE isoforms correspond with distinct tau oligomer polymorphs with varying synaptotoxicity. These findings highlight the need for APOE isoform to be considered when generating tau-based therapies for Alzheimer's disease. Specific targeting of APOE isoform-specific tau oligomer polymorphs could provide a novel method of mitigating Alzheimer's Disease pathology and combating disease progression.
Authors
- Rakez Kayed
- Naomi Moreno (ORCID: https://orcid.org/0000-0003-0482-1394)
- Md. Anzarul Haque (ORCID: https://orcid.org/0000-0002-4603-6565)
- Nemil Bhatt (ORCID: https://orcid.org/0000-0001-5017-7312)
- Agenor Limón (ORCID: https://orcid.org/0000-0002-6613-770X)
- Nikita Shchankin
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106052
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00