Behavioral and neuronal substrates of serious game‐based computerized cognitive training in cognitive decline related to Alzheimer's Disease

This RCT indicates no specific advantages of a three-month CCT intervention on cognitive or biological outcomes. However, the consistently high adherence rates observed in this study highlight the importance of designing interventions that align with personal relevance and individual values, particularly in subjects with SCD and MCI who demonstrated high motivation to engage in healthy aging behaviors. Further, positive effects were observed subjectively and after long-term CCT, warranting the inclusion of CCT in multicomponent interventions.