Increased <i>Cdkn2a</i> , a regulator of cellular senescence, in the PS19 mouse model of tauopathy
These data indicate selective astrocytic over-expression of both Cdkn2a transcripts has minimal effects on the behavior of NonTg mice. Over-expression of both Cdkn2a transcripts in PS19 mice improved pre-pulse inhibition but had no impact on other affective behavioral tasks or learning behavioral tasks.
Authors
- Dylan J. Finneran (ORCID: https://orcid.org/0000-0001-7593-9432)
- Marcia N. Gordon (ORCID: https://orcid.org/0000-0002-4051-9283)
- Taylor Desjarlais
- Briana G Jackman
- Dave Morgan
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107206
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00